RTA dephosphorylation mediated by phosphatase PP2A is conserved among rhadinoviruses.

<p>(A) Phosphatase PP2A inhibitor LB-100 enhances the phosphorylation of MHV68 RTA. HEK293T cells were transfected with 2 μg MHV68 RTA plasmids. At 24 hours after transfection, cells were treated with LB-100 (5 μM) or PBS for 48 hours. WCLs were immunoprecipitated with anti-Flag antibody follo...

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Autor principal:	Lei Bai (631944) (author)
Otros Autores:	Lianghui Dong (7908431) (author), Jiazhen Dong (595963) (author), Xiaowei Liang (4721025) (author), Jiangwei Peng (21524781) (author), Yuncai Chen (7541564) (author), Xiaoyi Sun (2323519) (author), Yuting Chen (151583) (author), Xintong Li (3110796) (author), Hua Cai (15034) (author), Jing Huang (41604) (author), Zixu Cao (22772675) (author), Ke Lan (232754) (author)
Publicado:	2025
Materias:	Biochemistry Microbiology Cell Biology Molecular Biology Evolutionary Biology Cancer Science Policy Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified provide new insights new binding partner human &# 947 host antiviral mechanism scaffold protein ppp2r1a promote ppp2r1a degradation initiating lytic replication kshv progeny virions viral lytic replication lytic replication ppp2r1a overexpression encoded replication viral latency transcription factor transcription activity transcription activator taken together proteasome pathway pharmacological agonist next demonstrated life cycle fully elucidated extensive studies central role
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RTA dephosphorylation mediated by phosphatase PP2A is conserved among rhadinoviruses.

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