VDAC1-MCU channels mediate mitochondrial Ca2+ entry and mitochondrial fission.

(A-H) Marc-145 cells were infected with PRRSV (MOI = 0.1) for 24 h with or without VBIT-12 (A-D) or MCU-i4 (E-H) treatment. (A and E) Ca2+ was detected by flow cytometry after Rhod-2 staining. (B and F) The cells were analyzed by confocal microscopy after staining wit...

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Main Author:	Zhe Sun (328682) (author)
Other Authors:	Zicheng Ma (14071216) (author), Wandi Cao (20553288) (author), Chenlong Jiang (14071219) (author), Lei Guo (36221) (author), Kesen Liu (9086343) (author), Yanni Gao (6250973) (author), Juan Bai (798838) (author), Jiang Pi (817619) (author), Ping Jiang (243020) (author), Xing Liu (221084) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Neuroscience Physiology Cancer Science Policy Infectious Diseases Plant Biology Virology Environmental Sciences not elsewhere classified “ powerhouse ” providing new insights promoting cellular glycolysis mams ), mediated ip3r )— voltage generating cellular energy excessive lactate production camkkβ )— amp ampk )— dynamin activated protein kinase regulates mitochondrial function mitochondrial dynamics proteins hijack mitochondrial function promote mitochondrial fission mediated mitochondrial fission induced mitochondrial fission induce mitochondrial fission alongside mitochondrial fission related protein 1 triggers mitophagy via mitophagy drive glycolysis respiratory syndrome virus div >< p 2 +</ sup elevated mitochondria ca mitochondrial ca inositol 1 elevated levels vital role upregulated expression triphosphate receptor study reveals sigmar1 ). sigma non mitochondria ca increased mitochondria evolved mechanisms endoplasmic reticulum dynamic processes 49 kda
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VDAC1-MCU channels mediate mitochondrial Ca<sup>2+</sup> entry and mitochondrial fission.

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