Hydrophilic Interaction Liquid Chromatography-Based Enrichment Method for Deciphering the N‑Phosphorylated Proteome Landscape

Protein N-phosphorylation, especially in mammals, was gradually studied and attracted widespread attention. However, the lack of effective enrichment methods resulted from the intrinsic lability of the P–N bond under acidic conditions, which seriously hindered biological function elucidation. In thi...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Bo Gao (106513) (author)
مؤلفون آخرون:	He Wang (250350) (author), Shuxian Wei (2224873) (author), Yuqi Zeng (17862338) (author), Qianqian Jiang (1448770) (author), Zichun Qiao (13913760) (author), Baofeng Zhao (479410) (author), Zhen Liang (659089) (author), Yukui Zhang (1413592) (author), Jianbo Qu (10320839) (author), Lihua Zhang (22614) (author), Bo Jiang (76119) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Cell Biology Molecular Biology Neuroscience Biotechnology Cancer Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified lung cancer cells high brain metastasis hela cell membrane attracted widespread attention also enabled profiling possible sites involved previous enrichment methods hilic stationary phase based enrichment method phosphorylation sites identified phosphorylation sites new method based strategy phosphorylation enrichment various samples tumor diagnosis tool box taken together regulating invasion potential targets phosphorylation analysis phosphoproteome landscape neutral conditions intrinsic lability hydrophilic two escherichia coli enhanced hydrophilicity dynamic change dimensional nanocomposites could provide coordination interaction acidic conditions
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Hydrophilic Interaction Liquid Chromatography-Based Enrichment Method for Deciphering the N‑Phosphorylated Proteome Landscape

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