Biphasic Coacervation Controlled by Kinetics as Studied by De Novo-Designed Peptides

Coacervation is generally treated as a liquid–liquid phase separation process and is controlled mainly by thermodynamics. However, kinetics could make a dominant contribution, especially in systems containing multiple interactions. In this work, using peptides of (XXLY)<sub>6</sub>SSSGSS...

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Bibliographic Details
Main Author:	Tianhao Ren (17494851) (author)
Other Authors:	Dehai Liang (12112) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Molecular Biology Developmental Biology Infectious Diseases Virology Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified Information Systems not elsewhere classified xxly )< sub major driving force introduce secondary structures 6 </ sub phase separation process biphasic coacervates formed coacervation processes controlled biphasic coacervation controlled varying ph values kinetics could make designed peptides coacervation dependent electrostatic interaction coacervation process electrostatic interaction controlled mainly observe coacervates hydrophobic interaction using peptides stranded oligonucleotides quaternized dextran practical approach peptides takes minimized sequences living cells leading role kinetics negligible kinetics controls kinetic control generally treated functions due early stage dominant contribution different morphologies de novo charge density
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Biphasic Coacervation Controlled by Kinetics as Studied by De Novo-Designed Peptides

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