Quantitative proteomic analysis to define the protein signature in the HAND brains.

<p>A Proteomic Experimental Design: Five sets of 11-plex Tandem Mass Tags (TMT) were used to quantify and identify proteins in HAND+ brain samples compared to control brain samples. The figure was created using BioRender. B The top biological pathways identified from the 30 significantly alter...

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Main Author:	Yuyang Tang (124043) (author)
Other Authors:	Ling Xie (2026981) (author), Ciniso Sylvester Shabangu (18236013) (author), Dajiang Li (3819199) (author), Gabriela da Silva Prates (15229642) (author), Ashokkumar Manickam (22097256) (author), Lilly M. Wong (12221774) (author), Antoine Chaillon (309416) (author), Edward P. Browne (8913893) (author), Sara Gianella (196115) (author), Wenzhe Ho (332788) (author), David M. Margolis (244046) (author), Xian Chen (107385) (author), Wenhui Hu (80326) (author), Guochun Jiang (777612) (author)
Published:	2025
Subjects:	Biophysics Cell Biology Genetics Molecular Biology Neuroscience Physiology Immunology Developmental Biology Cancer Mental Health Infectious Diseases Biological Sciences not elsewhere classified present &# 8212 last gift cohort increased &# 8212 human endogenous retrovirus cell rna sequencing 7 %&# 8212 associated neurocognitive disorders also highly active happen without hiv brain tissues collected brain organoid model acute hiv infection immune response pathways glial cells even interferon signaling within remains active endothelial cells cognitive disorders xlink "> using single unrelated mechanisms rapid autopsies protein profiles negative controls molecular mechanism may contribute hand ), findings point especially strong directly trigger better understand antiretroviral therapy 9 hand 27 brains
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Quantitative proteomic analysis to define the protein signature in the HAND brains.

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