<i>De Novo</i> Peptides That Induce the Liquid–Liquid Phase Separation of α‑Synuclein

Liquid–liquid phase separation (LLPS) of proteins can form membraneless organelles in the cell and can lead to pathological aggregation associated with neurodegenerative diseases. However, progress in controlling LLPS has been limited, and there has been no emergence of engineered <i>de novo&l...

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Detalles Bibliográficos
Autor Principal:	Tatsuya Ikenoue (1809706) (author)
Outros autores:	Masatomo So (1532092) (author), Naohiro Terasaka (4731153) (author), Wei-En Huang (4508617) (author), Yasushi Kawata (341700) (author), Yohei Miyanoiri (6918842) (author), Kiyoto Kamagata (1597108) (author), Hiroaki Suga (295809) (author)
Publicado:	2025
Subjects:	Biophysics Biochemistry Cell Biology Physiology Pharmacology Immunology Inorganic Chemistry Space Science Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified pathological aggregation associated form membraneless organelles de novo </ peptides primarily interact efficient droplet formation therapeutic intervention terminal region study demonstrates specific peptides protein involved promising tool parkinson ’ neurodegenerative diseases interaction network fundamental investigations amyloid diseases
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<i>De Novo</i> Peptides That Induce the Liquid–Liquid Phase Separation of α‑Synuclein

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