BRD4 regulates KSHV inducible gene expression in the TR dependent manner.

(A). Immunofluorescence image of the LANA protein in TR5-KSHV or TR21-KSHV-infected iSLK cells. Anti-LANA rat monoclonal antibody and alexa-647 (secondary) goat anti-rat antibody were used for staining LANA in TR5- or TR21-KSHV-infected iSLK cells and C...

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Autor Principal:	Tomoki Inagaki (12903779) (author)
Outros autores:	Ashish Kumar (152984) (author), Kang-Hsin Wang (12691954) (author), Somayeh Komaki (17350755) (author), Jonna M. Espera (22784197) (author), Christopher S. A. Bautista (22784200) (author), Ken-ichi Nakajima (622199) (author), Chie Izumiya (449437) (author), Yoshihiro Izumiya (449433) (author)
Publicado:	2025
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Immunology Developmental Biology Cancer Science Policy Infectious Diseases Virology specific genomic region de novo </ shortened dna template ef1α promoter encoded infected kshv episomes generated recombinant kshv viral gene promoters tr copy numbers tr copy number intrinsically disordered domain inducible lana degradation containing protein 4 inducible promoter activation tr dna fragments brd4 interacts flexibly supported kshv reactivation kshv tr functions previous studies demonstrated div >< p smaller lana nbs studied brd4 recruitment larger lana nbs prior transcription activation reactivating cells confirmed prior activation promoter dynamics larger brd4 dna bindings brd4 recruitment tr length impaired reactivation containing llps gene enhancer enhancer domain brd4 occupancies transcription memories transcription factor terminal repeats tagged proteins separated dots results suggest related proteins purified fluorescence liquid phase kaposi ’ global attenuation genome contains form liquid either due decreased efficacy
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BRD4 regulates KSHV inducible gene expression in the TR dependent manner.

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