Discovery of a Novel 1,4-Benzodiazepine Derivative as a Highly Selective ANXA3 Degrader for the Treatment of Triple-Negative Breast Cancer

Discovery of a Novel 1,4-Benzodiazepine Derivative as a Highly Selective ANXA3 Degrader for the Treatment of Triple-Negative Breast Cancer

Annexin A3 has been demonstrated to be a key pathogenic protein in the occurrence and development of triple-negative breast cancer (TNBC); its overexpression in TNBC cells can promote the proliferation, migration, and drug resistance of TNBC. Previously, we reported the first ANXA3 degrader, (<i&...

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Bibliographic Details
Main Author: Kunlin Liu (6388580) (author)
Other Authors: Chenhao Zhu (8962280) (author), Yongxi Liang (5536487) (author), Delin Min (20795184) (author), Zijun Jin (18827377) (author), Xun Sun (364650) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Cell Biology
Pharmacology
Biotechnology
Cancer
Infectious Diseases
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
negative breast cancer
key pathogenic protein
first anxa3 degrader
promising lead compound
sl18 </ b
18a5 </ b
anxa3 binding activity
r </
stronger binding
functional activity
>< b
>)-< b
target effects
structural optimization
potent anti
obtain molecules
lower toxicity
fold increase
family proteins
drug resistance
benzodiazepine derivative
96 %).
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