The fluorescence of FAM-myristoyl-H4K16 peptide does not significantly change when bound to SIRT2 alone.

<p>In this experiment, the fluorescence of 50 nM FAM-myristoyl-H4K16 peptide was measured in the presence or absence of 1 μM SIRT2 (excitation/emission wavelengths were 340 nm/520 nm, similar to HTRF assays). The fluorescence intensity differed by only 9.5% between the two conditions.</p>...

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Bibliographic Details
Main Author:	Jie Yang (121778) (author)
Other Authors:	Joel Cassel (3024222) (author), Brian C. Boyle (18874291) (author), Daniel Oppong (18874294) (author), Young-Hoon Ahn (1310325) (author), Brian P. Weiser (1583176) (author)
Published:	2024
Subjects:	Biochemistry Cell Biology Molecular Biology Pharmacology Biotechnology Developmental Biology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified protein lysine residues attractive drug target 7 &# 956 37 &# 956 throughput screen based two small fragments independently inhibited sirt2 div >< p inhibited sirt2 ’ resolved fluorescence screen identify sirt2 deacetylase resolved fluorescence sirt2 ’ test screen small molecule identify inhibitors deacetylase activity human sirtuin homogeneous time demyristoylase activity binding assay 9600 compounds
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The fluorescence of FAM-myristoyl-H4K16 peptide does not significantly change when bound to SIRT2 alone.

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