Relative expression levels of 17 myocardial-specific genes in human iPS cell-derived engineered heart tissues (hiPSC-EHTs) cultured in three candidate media compared to that in the left ventricle.

<p>hiPSC-EHTs were cultured in iCell cardiomyocyte maintenance medium for 3 weeks and then in the EHT medium for over 1 week. Thereafter, hiPSC-EHTs were cultured in the three candidate media for 72 h. The graph bar shows the average mean, and the error bar shows the standard error (n = 4).<...

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Bibliographic Details
Main Author:	Shinichiro Horiuchi (17800001) (author)
Other Authors:	Nanae Koda (20469136) (author), Yui Ikeda (20469139) (author), Yuto Tanaka (11362035) (author), Yusuke Masuo (526998) (author), Yukio Kato (430483) (author), Daiju Yamazaki (3385316) (author)
Published:	2024
Subjects:	Biochemistry Medicine Cell Biology Physiology Pharmacology Cancer Science Policy Space Science Chemical Sciences not elsewhere classified investigated candidate media engineered heart tissue div >< p develop alternative approaches innocell plate increased findings may facilitate human ips cell hepatic metabolism cannot hepatic drug metabolism drug cardiotoxicity associated based microphysiological system common culture medium improved oxygenation using eht medium used hepatic metabolism improved oxygenation cardiotoxicity associated medium used may allow hepatic function also increased used commonly human liver eht cultured eht culture vitro </ typical inducers stable throughout significantly greater serious concern results suggest relaxation speed related gene nuclear receptors major cyps lowering costs evaluated using ethical concerns detected using cyp3a4 activity cyp3a4 </ cyp </ culture period contraction speed contraction length beating rate
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Relative expression levels of 17 myocardial-specific genes in human iPS cell-derived engineered heart tissues (hiPSC-EHTs) cultured in three candidate media compared to that in the left ventricle.

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