Microglial activation induced by injecting recombinant HAPLN2 protein into the mouse hippocampus.

<p>(A) Filter trap assay and immunoblot analysis of recombinant full-length HAPLN2, HAPLN2 Ig-like domain, and oxStayGold proteins. These recombinant proteins (2 µM each) were incubated overnight at 37°C, followed by centrifugation at 100,000 <i>g</i> for one hour at 4°C. (B) Immu...

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Autor principal:	Ayaka Watanabe (22057715) (author)
Altres autors:	Shoshiro Hirayama (776671) (author), Itsuki Kominato (22057718) (author), Sybille Marchese (22057721) (author), Pietro Esposito (11932931) (author), Vanya Metodieva (19286361) (author), Taeko Kimura (538348) (author), Hiroshi Kameda (11337612) (author), Terunori Sano (19142317) (author), Masaki Takao (754166) (author), Sho Takatori (1734199) (author), Masato Koike (209042) (author), Juan Alberto Varela (22057724) (author), Taisuke Tomita (410925) (author), Shigeo Murata (462393) (author)
Publicat:	2025
Matèries:	Biophysics Biochemistry Cell Biology Genetics Neuroscience Physiology Immunology Developmental Biology Cancer Mental Health Infectious Diseases Biological Sciences not elsewhere classified promotes microglial inflammation elderly individuals without div >< p dependent aggregating protein hapln2 aggregation results hapln2 forms aggregates mice </ p associated hapln2 aggregation protein aggregation protein aggregates associated changes hapln2 ), vivo </ vitro </ binding protein related decline neurodegenerative diseases may exacerbate investigated proteins identified hyaluronan hyaluronic acid human cerebellum findings suggest extracellular matrix comprehensive understanding brain homeostasis brain environment brain aging become sarkosyl also observed aging drives activating microglia
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Microglial activation induced by injecting recombinant HAPLN2 protein into the mouse hippocampus.

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