The nature of products after TDGFL-catalysed cleavage of 41-mer dmbDNA substrates containing either a G•T* mispair or an A•T* pair.

dmbDNA with the 32P-labelled bottom 55-mer strand containing T at position 26 opposite to G (lanes 1–5) or A (lanes 6–10) was incubated with TDGFL for 1 h (lanes 1–5) or 18 h (lanes 6–10) and post-treated with hot alkali (NaOH), light piperidine...

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Bibliographic Details
Main Author:	Diana Manapkyzy (19871017) (author)
Other Authors:	Botagoz Joldybayeva (542447) (author), Alexander A. Ishchenko (9693725) (author), Bakhyt T. Matkarimov (19871020) (author), Dmitry O. Zharkov (542449) (author), Sabira Taipakova (9693716) (author), Murat K. Saparbaev (345036) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Developmental Biology Cancer turnover conditions shows isolated catalytic domain experimental conditions used cleavage product accumulation apparent rate constant 85 – 330 extended incubation time active dna demethylation sup >&# 8722 47 – 0 0014 – 0 specific dna duplex damaged dna duplex div >< p cpg binding domain containing protein 4 37 ° c regular dna duplexes fl </ sup base excision repair • g mispairs duplex dna vivo </ time course base pairs dna glycosylase terminal domains strand breaks regular non physiologically relevant overall conformation mitotic cells methylcytosine residues human thymine gene expression fold lower equimolar concentrations epigenetic regulation disordered n dependent removal cpg contexts cpg context also involved 61 min 5hmc residues 5hmc ), 0069 min
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The nature of products after TDG<sup>FL</sup>-catalysed cleavage of 41-mer dmbDNA substrates containing either a G•T* mispair or an A•T* pair.

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