3D Tumor-Mimicking Phantom Models for Assessing NIR I/II Nanoparticles in Fluorescence-Guided Surgical Interventions

Fluorescence image-guided surgery (FIGS) offers high spatial resolution and real-time feedback but is limited by shallow tissue penetration and autofluorescence from current clinically approved fluorophores. The near-infrared (NIR) spectrum, specifically the NIR-I (700–900 nm) and NIR-II (950–1700 n...

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Bibliographic Details
Main Author:	Asma Harun (21377600) (author)
Other Authors:	Nathaniel Bendele (21377603) (author), Mohammad Ibrahim Khalil (9199466) (author), Isabella Vasquez (17918539) (author), Jonathan Djuanda (21377606) (author), Robert Posey (21377609) (author), Md. Hasnat Rashid (21377612) (author), Gordon F. Christopher (6533372) (author), Ulrich Bickel (2317984) (author), Viktor Gruev (3975329) (author), Joshua Tropp (6311507) (author), Paul F. Egan (4348633) (author), Indrajit Srivastava (3699535) (author)
Published:	2025
Subjects:	Medicine Cell Biology Physiology Pharmacology Biotechnology Cancer Science Policy Space Science Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified phantoms often fail mimicking phantoms used like nanoparticle concentrations clinically relevant assessments biologically relevant factors shallow tissue penetration deeper tissue penetration vivo mouse studies tumor margin delineation suboptimal optical performance propose developing tumor ex vivo tumors superior surgical utility mimicking phantom models light scattering components ii imaging systems vivo mouse models existing tissue tumor microenvironment optical profiles 3d tumor surgical environments surgical conditions world surgeries time feedback throughput platform shown promise screening nanoprobes realistic conditions predictive assessment preclinical findings porcine lungs noise ratios intralipid ). improved signal ii probes ii nanoprobes ii nanoparticles hemoglobin ), guided surgery fall short closely match clinical translation clinical applications biological barriers assessing nanoprobes
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3D Tumor-Mimicking Phantom Models for Assessing NIR I/II Nanoparticles in Fluorescence-Guided Surgical Interventions

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