Evolved clone mutations.

<div><p>Organelles and endosymbionts have naturally evolved dramatically reduced genome sizes compared to their free-living ancestors. Synthetic biologists have purposefully engineered streamlined microbial genomes to create more efficient cellular chassis and define the minimal componen...

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Bibliographic Details
Main Author:	Isaac Gifford (5842667) (author)
Other Authors:	Gabriel A. Suárez (19681600) (author), Jeffrey E. Barrick (232269) (author)
Published:	2024
Subjects:	Biochemistry Microbiology Cell Biology Genetics Evolutionary Biology Infectious Diseases Computational Biology Biological Sciences not elsewhere classified frequently mutated across evolved replicate populations endpoint clonal isolates div >< p efficient cellular chassis two small rnas acinetobacter baylyi </ engineered genome streamlining bacterial fitness varied certain deletion ancestors deletion strains restored genome streamlining two ancestors cellular life living ancestors two strains two environments rnd </ hfq </ csra </ earlier deletion deletion strain ancestral deletion unknown reasons transcriptional regulators synthetic biologists specific targets specific compensation six variants significantly associated results demonstrate regained rapidly recovery tends minimal components many non larger deletions large deletions laboratory evolution kilobase region global post fitness lost fitness increased examined except evolution recovers evolution environment essential genes different 22 complex medium coding genes binding protein 300 generations 293 kilobases
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Evolved clone mutations.

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