Precise Discovery of Novel N‑Terminal Proteoforms beyond the Limitations of Proteogenomics and <i>De Novo</i> Sequencing

Alternative splicing-mediated protein N-terminal sequence variation is closely associated with diseases, but its identification by mass spectrometry faces technical bottlenecks. Traditional proteogenomic methods cannot identify novel N-terminal proteins undetected in transcriptome data, while <i&...

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Bibliographic Details
Main Author:	Cuitong He (5446760) (author)
Other Authors:	Ke Su (602528) (author), Huanju Liu (18445044) (author), Lihao Jin (21802403) (author), Tingting Xu (307597) (author), Chenyang Mu (21802406) (author), Fu Yang (101882) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Genetics Molecular Biology Biotechnology Developmental Biology Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified recently reported aag peptide encoding mechanisms parse signature peptides first dedicated algorithm enables tracing back de novo </ mediated protein n terminal sequence variation terminal extension peptides mass spectrometry data human genes calm2 validated novel n initiated novel n terminal proteins undetected sequencing alternative splicing scale proteogenomics failed novel n terminal proteins terminal proteoforms transcriptome data human atp9a translational frameshifting specifically designed sequencing algorithms rigorous validation precise discovery essential complement conventional approaches closely associated actually generated
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Precise Discovery of Novel N‑Terminal Proteoforms beyond the Limitations of Proteogenomics and <i>De Novo</i> Sequencing

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