Proteomic Comparison between Hyphae and Spores Reveals Pathogenicity of Mucor Irregularis

Mucor irregularis, an emerging causative agent of disfiguring mucormycosis, demonstrates distinct clinical manifestations between hyphae and spore forms, though the pathogenic determinants between these two forms remain elusive. Utilizing TMT (tandem mass tag)-based quantitative proteomics (Proteome...

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Autore principale:	Meijie Zhang (8638596) (author)
Altri autori:	Xiaowei Zhou (1332225) (author), Yuhan Zhang (2792089) (author), Ge Song (1754242) (author), Xiaofang Li (212165) (author), Weida Liu (848554) (author), Guanzhao Liang (8334150) (author)
Pubblicazione:	2025
Soggetti:	Biochemistry Microbiology Genetics Molecular Biology Ecology Cancer Plant Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified trna sulfur modification spores reveals pathogenicity spores contrasts sharply rhogef gtpases central future investigations must emerging causative agent dependent mitochondrial function upregulated virulence determinants first proteomic profiling spore dormancy maintenance proteomic comparison pathogenic determinants spore readiness spore forms utilizing tmt specific adaptations pxd055430 ), metabolic activation immunomodulatory roles hyphal invasion host invasion gene ontology effector proteins disfiguring mucormycosis comparative analysis building upon associated machinery adenylate kinase
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Proteomic Comparison between Hyphae and Spores Reveals Pathogenicity of Mucor Irregularis

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