NPC1 deficiency in WMR microglia promotes a more ameboid shape phenotype at P7.

NPC1 deficiency in WMR microglia promotes a more ameboid shape phenotype at P7.

<p>A. IBA1 immunoreactivity in cerebella from WT and <i><i>Npc1</i></i><sup><i>nmf164</i></sup> mice at P7. B. Quantitative analysis of the density of IBA1<sup>+</sup> cells in WT and <i><i>Npc1</i></i><sup&...

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Bibliographic Details
Main Author:	Caroline E. Murray (22190338) (author)
Other Authors:	David S. Betancourt-Trompa (22190341) (author), Michael S. Martinez (22190344) (author), Julia M. Carson (22190347) (author), Lindsay J. Walsh (22190350) (author), Will C. Remillard (22190353) (author), Kayla B. Fordyce (22190356) (author), Rohan Reddy (18217185) (author), Ileana Soto (531878) (author)
Published:	2025
Subjects:	Cell Biology Genetics Molecular Biology Neuroscience Physiology Pharmacology Immunology Developmental Biology Cancer Science Policy Environmental Sciences not elsewhere classified s6 ribosomal protein postnatal developmental alterations postnatal day 7 morphological changes indicative innervate pc dendrites including increased proliferation alter microglial phenotypes >< sup >< drives postnatal activation rapamycin enhanced myelination early postnatal development associated microglia located microglial precursors within enhanced phagocytic activity div >< p inhibiting mtorc1 signaling increased mtorc1 activation mtorc1 activation contributes early cerebellar pathology rapamycin complex 1 postnatal ml microglia phagocytic activity microglial proliferation microglial precursors mtorc1 signaling cerebellar microglia pc loss ></ sup aberrant activation treated groups soma size show evidence purkinje cells ps6r ), p21 reduced npc1 </ nmf164 </ molecular layer findings demonstrate elevated clec7a downstream target activated state
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