Spike amino acid substitution Y623H triggers a conformational change leading to opening of the RBDs.

<p><b>(a-b)</b> Overview of the WIV1-CoV spike trimer (PDB: 8WQ0 [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1013123#ppat.1013123.ref011" target="_blank">11</a>]). The boxed region corresponds to the 630 loop in monom...

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المؤلف الرئيسي:	Alexandra L. Tse (20235212) (author)
مؤلفون آخرون:	Gorka Lasso (215085) (author), Jacob Berrigan (11052951) (author), Jason S. McLellan (8816639) (author), Kartik Chandran (134142) (author), Emily Happy Miller (10652108) (author)
منشور في:	2025
الموضوعات:	Neuroscience Evolutionary Biology Cancer Infectious Diseases Virology significant zoonotic threat mammalian respiratory tract host protease barrier genetic pathways associated even initially replace poor entry activity key viral adaptation entry could precede alters spike dynamics increased spike opening enhances spike opening xlink "> sars s1 &# 8211 loop &# 8217 enhance spike cleavage opening substitutions arose bat sarbecovirus wiv1 cov spikes could viral entry &# 8217 opening substitutions s2 cleavage s1 subunit cell entry &# 8216 type spike spike resembling successful isolation single amino s2 boundary rhinolophid bats pseudotype system previously showed previously identified oral lifestyle natural hosts like betacoronaviruses incompletely understood immune evasion findings suggest currently recognized cov using cov bears conformational constraints cell culture broader property binding domain bats pose bat sarbecoviruses adaptive mutation
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Spike amino acid substitution Y623H triggers a conformational change leading to opening of the RBDs.

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