Figure 2 from Screening FDA-Approved Oncology Drugs with Three-Dimensional Spheroids Identifies Romidepsin as a Therapeutic Candidate for Osteosarcoma

Figure 2 from Screening FDA-Approved Oncology Drugs with Three-Dimensional Spheroids Identifies Romidepsin as a Therapeutic Candidate for Osteosarcoma

<p>Top hits of initial screen are HDIs, proteasome inhibitors, and topoisomerase inhibitors. <b>A,</b> Screen of FDA-approved oncology drugs on sarcospheres generated from 143B, MG63.3-GFP, and LM7 cell lines. Heatmap shows inhibition of growth in blue and little or no effect in re...

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Main Author: Emily E. Seiden (22436851) (author)
Other Authors: Spencer M. Richardson (22436854) (author), Leah A. Everitt (22436857) (author), Gabrielle J. Knafler (22436860) (author), Alyssa L. Walker (22436863) (author), Venetia A. Whiteside (22436866) (author), Divya Pillutla (22436869) (author), Shrey Ramnath (22436872) (author), Gavin P. Kinsella (22436875) (author), Piper A. Wilburn (22436878) (author), James D. Buschbach (22436881) (author), Deep A. Gandhi (22436884) (author), M. Reza Saadatzadeh (22436887) (author), L. Daniel Wurtz (22436890) (author), Patrick J. Getty (22436893) (author), Sheldon L. Padgett (22436896) (author), Rance M. Gamblin (22436899) (author), Michael O. Childress (22436902) (author), Christopher M. Fulkerson (15090300) (author), Maegan L. Capitano (22436905) (author), Karen E. Pollok (21365488) (author), Christopher D. Collier (21365482) (author), Edward M. Greenfield (22436908) (author)
Published: 2025
Subjects:
Cancer
Tumor Biology
Therapeutic Research and Development
Methods and Technology
Drug Discovery Technologies
Screening strategies (assays and chemical libraries)
In Vitro Models Of Cancer
Progression, Invasion & Metastasis
Tumor progression
Pediatric Cancers
Sarcomas
Osteosarcoma
Small Molecule Agents
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