RORγ and SREBP2 synergistically enhance viral replication.

<p>(A and B) NL20 cells seeded in a 12-well plate were incubated in the absence or presence of the indicated concentrations of XY018 (A) or fatostatin minus or plus XY018 (1 μM) (B) for 16 and 24 h. (C and D) SREBP2 cooperates with RORγ to enhance IAV replication. NL20 cells were transiently t...

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Bibliographic Details
Main Author:	Jingting Zhang (791900) (author)
Other Authors:	Ruixuan Cao (22493337) (author), Yujie Wang (308942) (author), Yuling Sun (5688665) (author), Xiaoyue Ji (14272545) (author), Penggang Liu (2512177) (author), Kaituo Liu (10512226) (author), Jing Sun (141206) (author), Xiaojun Chen (317104) (author), Demin Cai (621171) (author), Pinghu Zhang (4029842) (author), Xiaoquan Wang (305826) (author), Xiufan Liu (26081) (author), Xiulong Xu (342383) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Immunology Cancer Science Policy Mental Health Infectious Diseases Plant Biology Virology xlink "> infection turn activate ap1 supply substantial amounts sterol regulatory element orphan nuclear receptor ror &# 947 facilitate &# 160 nf -&# 954 exogenous cholesterol rescues iav infection induces axis </ p induced hmgcr expression xy018 treatment reduces facilitate virus replication &# 954 hmgcr ), cholesterol biosynthesis cellular cholesterol viral replication terminal kinase suppress iav retinoic acid prolongs survival methylglutaryl coenzyme key enzyme jun n inhibitory effect infected mice ikk ), downstream kinases
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RORγ and SREBP2 synergistically enhance viral replication.

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