Stimulating PV cells at nonsilencing levels during entire stimulus presentation or late phase V1 activity impairs discrimination performance, whereas stimulating during early phase V1 activity improves performance.

Stimulating PV cells at nonsilencing levels during entire stimulus presentation or late phase V1 activity impairs discrimination performance, whereas stimulating during early phase V1 activity improves performance.

<p><b>A)</b> Example of grating stimuli separated by 90° for easy task (top), schematic of optogenetic manipulations activating only PV cells expressing ChR2 (middle), optogenetic stimulation timings for all four conditions aligned to stimulus onset (STIM ON) or offset (STIM OFF) (...

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Detalhes bibliográficos
Autor principal: Lilia Kukovska (22683586) (author)
Outros Autores: Katharina A. Wilmes (22683589) (author), Natsumi Y. Homma (22683592) (author), Claudia Clopath (324706) (author), Jasper Poort (22683595) (author)
Publicado em: 2025
Assuntos:
Biochemistry
Neuroscience
Developmental Biology
Science Policy
Mental Health
Biological Sciences not elsewhere classified
xlink "> inhibition
three major factors
strong competitive interactions
photon imaging showed
balanced cortical activity
primary visual cortex
sustained v1 activity
combined optogenetic activation
v1 cells captured
moderate pv activation
moderate activation
visual discriminations
expressing cells
nonlinear activation
dependent activation
activation strength
task difficulty
stimulus onset
perceptual discrimination
difficult discriminations
delineates conditions
circuit model
behavioral effects
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