Inhibition of SR Protein Phosphorylation Impairs IRES-Dependent Translation and Attenuates EV-A71 Replication.

<p>(A) Effects of SR protein kinase inhibitor (SRPKIN-1, 200 nM) and Clk kinase inhibitor (TG003, 50 μM) on SR protein phosphorylation and viral protein expression were analyzed by western blotting using pan-SR (α-SR) and pan-phospho-SR (α-pSR) antibodies. Unless otherwise indicated, the same...

Full description

Saved in:

Bibliographic Details
Main Author:	Kuo-Ming Lee (74206) (author)
Other Authors:	Chih-Ching Wu (165883) (author), Yu-Ting Fan (21553646) (author), Huan-Jung Chiang (19739380) (author), Pei-Yi Lien (21553649) (author), Jui-Ping Wang (21553652) (author), Yhu-Chering Huang (110834) (author), Shin-Ru Shih (110819) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Microbiology Cell Biology Molecular Biology Biotechnology Immunology Cancer Infectious Diseases Virology phenomenon predominantly observed kinase inhibitors srpkin determined using pan temporal ribonucleoprotein complexes remodeling process involved sr protein phosphoregulation sr protein antibodies translation machinery rather stranded rna viruses late infection stages specific sr proteins phosphorylated sr proteins dependent translation revealed a71 infection induced early infection phase late phase infection process dependent translation protein composition competent complexes a71 infection proteins found associated proteins xlink "> virion assembly viral rnas viral rna significant challenge sense single quantitative proteomics promising strategy pivotal role nuclear serine mechanisms governing maturation phases including srsf4 findings underscore enterovirus a71 critical role conducted rna comparative analysis
Tags:	Add Tag No Tags, Be the first to tag this record!

Inhibition of SR Protein Phosphorylation Impairs IRES-Dependent Translation and Attenuates EV-A71 Replication.

Similar Items