Chemoproteomic Profiling of C. albicans for Characterization of Antifungal Kinase Inhibitors

Candida albicans is a major cause of systemic candidiasis, a severe fungal infection with a ∼40% mortality rate. Yck2, a casein kinase 1 (CK1) in C. albicans, is targeted by antifungal inhibitors YK-I-02 (YK) and MN-I-157 (MN). Using multiplexed inhibitor beads and mass spectrometry (MIB/MS), the se...

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المؤلف الرئيسي:	David J. Shirley (20907879) (author)
مؤلفون آخرون:	Meganathan Nandakumar (1796332) (author), Aurora Cabrera (7916339) (author), Bonnie Yiu (20907882) (author), Emily Puumala (12563822) (author), Zhongle Liu (159963) (author), Nicole Robbins (206417) (author), Luke Whitesell (477573) (author), Jeffrey L. Smith (12257228) (author), Scott Lyons (15170653) (author), Angie L. Mordant (16362957) (author), Laura E. Herring (3046809) (author), Lee M. Graves (425633) (author), Rafael M. Couñago (7309469) (author), David H. Drewry (386307) (author), Leah E. Cowen (7431083) (author), Timothy M. Willson (1276791) (author)
منشور في:	2025
الموضوعات:	Biochemistry Microbiology Genetics Neuroscience Pharmacology Biotechnology Immunology Cancer Infectious Diseases Plant Biology Virology Chemical Sciences not elsewhere classified human p38α homologue casein kinase 1 severe fungal infection profiling nonhuman kinomes albicans protein kinases antifungal inhibitors yk fungal kinome chemoproteomic profiling antifungal activity ∼ 40 systemic candidiasis new chemotype mortality rate mass spectrometry major cause kinobead confirmed findings highlight determined across chemoproteomics using antimicrobial agents
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Chemoproteomic Profiling of C. albicans for Characterization of Antifungal Kinase Inhibitors

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