Characterization of an Iterative Halogenase Acting on Ribosomal Peptides Underlies the Combinatorial Biosynthesis Logic of Lasso Peptides

Halogenation is commonly utilized in medicinal chemistry for the improvement of drug leads. Flavin-dependent halogenases (FDHs) are ubiquitous across all domains of life, yet iterative FDHs are rare in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs). He...

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Main Author:	Jin-Long Lu (11214882) (author)
Other Authors:	Jiao-Jiao Cui (6714899) (author), Zhe-Yang Hu (20759426) (author), Jin-Ming Di (3696214) (author), Yuan-Yuan Li (27693) (author), Jiang Xiong (5702207) (author), Yu-Meng Jiao (20759429) (author), Kun Gao (161056) (author), Jian Min (1965868) (author), Shangwen Luo (1331874) (author), Shi-Hui Dong (1893469) (author)
Published:	2025
Subjects:	Biochemistry Medicine Genetics Pharmacology Biotechnology Cancer Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified various ripp classes novel iterative fdh iterative halogenase acting include iterative catalysis employs unique protein crucial recognition sequence biosynthetic gene clusters bioinformatic analysis reveals translationally modified peptides fdh activity spectrum computational studies enable lasso peptides halogenation dichlorinated lasso peptides ribosomal peptides underlies yet iterative fdhs orchestrates nonsequential chlorination combinatorial biosynthesis logic lasso peptide biosynthesis lasso peptides ribosomal peptides combinatorial biosynthesis previous studies antibacterial activity peptide interactions leader peptide core peptide ubiquitous across terminal motifs tailoring enzymes study expands ripps ). ribosomally synthesized particularly dichlorination medicinal chemistry homologous fdhs heterologous expression drug leads distinct n dependent halogenases commonly utilized chl </
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Characterization of an Iterative Halogenase Acting on Ribosomal Peptides Underlies the Combinatorial Biosynthesis Logic of Lasso Peptides

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