Surface Proteomic Analysis Reveals the Presence of Noncanonical Cell Membrane Endoplasmic Reticulum Chaperones in High-Grade Gliomas

High-grade gliomas (HGG) are highly aggressive tumors, which are predominately fatal for adults and pediatric patients. Identifying cancer-selective therapeutic targets remains a critical unmet need. The overexpression of endoplasmic reticulum (ER) chaperones in various cancers is well documented. M...

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Autore principale:	Alexis Z Minchaca (22680460) (author)
Altri autori:	Jean Bertoldo (4920244) (author), Philipp Graber (22680463) (author), Dong-Hun Bae (22680466) (author), Nisitha Jayatilleke (15031800) (author), Chelsea Mayoh (9459377) (author), Brett W. Stringer (7216580) (author), Louise Ludlow (13519387) (author), Maria Kavallaris (54201) (author), Angelica M. Merlot (22680469) (author)
Pubblicazione:	2025
Soggetti:	Biochemistry Cell Biology Genetics Biotechnology Cancer Science Policy Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified tumor cells exhibit often escape detection highly aggressive tumors critical unmet need conventional bioinformatic pipelines surface expression levels atypical surface expression cancer selective targets surface protein levels grade gliomas high surface expression grade gliomas selective targeting identifying cancer well documented various cancers transcriptomics alone total protein surfaceome studies surfaceome analysis study examined study advances predominately fatal poor correlation pediatric patients neoplastic samples first time findings highlight endoplasmic reticulum devastating disease also highlight
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Surface Proteomic Analysis Reveals the Presence of Noncanonical Cell Membrane Endoplasmic Reticulum Chaperones in High-Grade Gliomas

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