RTA promotes PPP2R1A degradation through the ubiquitin-proteasome pathway during KSHV lytic replication.

<p>(A to D) iSLK.RGB (A and B) or iSLK.puro (C and D) cells were transfected with siRNAs as indicated. At 24 hours after transfection, cells were induced with doxycycline at different time points as indicated. The expression kinetics of RTA and PPP2R1A at indicated time points were detected by...

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Hlavní autor:	Lei Bai (631944) (author)
Další autoři:	Lianghui Dong (7908431) (author), Jiazhen Dong (595963) (author), Xiaowei Liang (4721025) (author), Jiangwei Peng (21524781) (author), Yuncai Chen (7541564) (author), Xiaoyi Sun (2323519) (author), Yuting Chen (151583) (author), Xintong Li (3110796) (author), Hua Cai (15034) (author), Jing Huang (41604) (author), Zixu Cao (22772675) (author), Ke Lan (232754) (author)
Vydáno:	2025
Témata:	Biochemistry Microbiology Cell Biology Molecular Biology Evolutionary Biology Cancer Science Policy Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified provide new insights new binding partner human &# 947 host antiviral mechanism scaffold protein ppp2r1a promote ppp2r1a degradation initiating lytic replication kshv progeny virions viral lytic replication lytic replication ppp2r1a overexpression encoded replication viral latency transcription factor transcription activity transcription activator taken together proteasome pathway pharmacological agonist next demonstrated life cycle fully elucidated extensive studies central role
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RTA promotes PPP2R1A degradation through the ubiquitin-proteasome pathway during KSHV lytic replication.

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