New Candidate Targets of AMP-Activated Protein Kinase in Murine Brain Revealed by a Novel Multidimensional Substrate-Screen for Protein Kinases

New Candidate Targets of AMP-Activated Protein Kinase in Murine Brain Revealed by a Novel Multidimensional Substrate-Screen for Protein Kinases

AMP-activated protein kinase (AMPK) is a heterotrimeric serine/threonine kinase that is involved in the maintenance of energy homeostasis and recovery from metabolic stresses both at the cellular and whole body level. AMPK is found in all tissues examined so far, and a number of downstream targets h...

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Bibliographic Details
Main Author: Roland D. Tuerk (8660466) (author)
Other Authors: Ramon F. Thali (8660469) (author), Yolanda Auchli (247893) (author), Helene Rechsteiner (8660472) (author), René A. Brunisholz (8660475) (author), Uwe Schlattner (18191) (author), Theo Wallimann (18196) (author), Dietbert Neumann (311099) (author)
Published: 2020
Subjects:
Biophysics
Biochemistry
Cell Biology
Genetics
Molecular Biology
Physiology
Pharmacology
Biotechnology
Immunology
Developmental Biology
Inorganic Chemistry
Infectious Diseases
Chemical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
appetite control
AMP-Activated Protein Kinase
murine brain lysates
column method
mass spectrometry
Novel Multidimensional Substrate-Screen
radiolabeled ATP
candidate substrate proteins
Recent work
phosphorylation events
energy homeostasis
pilot screen
New Candidate
Kinase assays
AMPK substrates
body level
Protein Kinases AMP-activated protein kinase
brain-specific substrates
kinase assays
radiolabeled proteins
SDS-PAGE
Murine Brain Revealed
AMPK targets
MALDI
53 AMPK-specific phospho-spots
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