Source data and statistical details for figures.

Source data and statistical details for figures.

<div><p>Amyloid precursor protein (APP)-null mice exhibit significant deficits in motor performance, including reduced grip strength and impaired locomotion; however, the underlying neurophysiological mechanisms remain unclear. In this study, we show that conditional knockdown of APP sel...

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Xehetasun bibliografikoak
Egile nagusia: Miao-Jin Ji (22676552) (author)
Beste egile batzuk: Tong-Xuan Wu (22676555) (author), Chenhao Tian (10801643) (author), Xiang Cao (298023) (author), Ruyuan Wei (22676558) (author), Yin-Yin Yang (301866) (author), Xinran Meng (11537536) (author), Huanyao Tang (22676561) (author), Tiantao Cui (22676564) (author), Jiao Yang (623531) (author), Xin Tang (134573) (author), Chao Liu (43092) (author)
Argitaratua: 2025
Gaiak:
Biochemistry
Cell Biology
Molecular Biology
Neuroscience
Physiology
Developmental Biology
Infectious Diseases
mediated sodium currents
deep cerebellar nucleus
aberrant firing patterns
specific app reconstitution
cerebellar motor control
app deficiency leads
electrophysiological analysis revealed
6 channel activity
motor performance
motor function
motor deficits
app selectively
purkinje cells
marked reduction
impaired locomotion
findings reveal
exogenous expression
essential role
dcn ).
conditional knockdown
behavioral deficits
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