GWAS loci with no functional evidence.

GWAS loci with no functional evidence.

<p>SigNet selects the gene (green rectangle) based on network connectivity with genes selected at other loci, over the closest gene in the locus to a GWAS SNP (gray rectangle). Pink ovals represent genes with Mendelian evidence; orange ovals represent exome-chip evidence; yellow ovals represen...

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Bibliographic Details
Main Author: Zeinab Mousavi (20521925) (author)
Other Authors: Marios Arvanitis (528431) (author), ThuyVy Duong (18426903) (author), Jennifer A. Brody (7743146) (author), Alexis Battle (434619) (author), Nona Sotoodehnia (143373) (author), Ali Shojaie (213568) (author), Dan E. Arking (7588586) (author), Joel S. Bader (205554) (author)
Published: 2025
Subjects:
Genetics
Molecular Biology
Evolutionary Biology
Developmental Biology
Marine Biology
Infectious Diseases
Biological Sciences not elsewhere classified
xlink "> motivation
wide association studies
snps ), associated
new bayesian method
span many genes
selects 56 genes
identified genetic variants
minimum distance gene
gwas loci overall
226 gwas loci
likely causal gene
gene distance
method builds
causal genes
poor loci
individual loci
across loci
causal variants
causal remains
nearby gene
mendelian genes
genes selected
usually single
usually affect
significance networks
pmp22 </
nucleotide polymorphisms
linkage disequilibrium
including disease
human traits
existing methods
disease risk
coding changes
cardiac electrophysiology
20 %)
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