Figure 3 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

Figure 3 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

<p>MEK1/2 mutations drive resistance to trametinib in BRAF<sup>G469V</sup>-driven DIPG cells. <b>A,</b> Protein structure representation of BRAF showing the mutant residue (shaded orange) for the observed G469 missense mutation observed in ICR-B169. Generated in COSMIC-...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Elisa Izquierdo (15110795) (author)
Άλλοι συγγραφείς: Diana M. Carvalho (5608127) (author), Alan Mackay (20972) (author), Sara Temelso (13755357) (author), Jessica K.R. Boult (14936256) (author), Giulia Pericoli (15121517) (author), Elisabet Fernandez (15121520) (author), Molina Das (15121523) (author), Valeria Molinari (15110798) (author), Yura Grabovska (14234303) (author), Rebecca F. Rogers (14941192) (author), Maria Antonietta Ajmone-Cat (15121526) (author), Paula Z. Proszek (14997741) (author), Mark Stubbs (1353564) (author), Sarita Depani (15121529) (author), Patricia O'Hare (15121532) (author), Lu Yu (14946738) (author), Georgia Roumelioti (15121535) (author), Jyoti S. Choudhary (9927836) (author), Matthew Clarke (3550808) (author), Amy R. Fairchild (15110801) (author), Thomas S. Jacques (15117937) (author), Richard G. Grundy (15018659) (author), Lisa Howell (15121538) (author), Susan Picton (3813571) (author), Jenny Adamski (11420832) (author), Shaun Wilson (5013728) (author), Juliet C. Gray (15121541) (author), Bassel Zebian (5986940) (author), Lynley V. Marshall (15110912) (author), Fernando Carceller (14945229) (author), Jacques Grill (15015216) (author), Maria Vinci (15121544) (author), Simon P. Robinson (14934318) (author), Michael Hubank (15104113) (author), Darren Hargrave (15016889) (author), Chris Jones (25458) (author)
Έκδοση: 2025
Θέματα:
Cancer
Therapeutic Research and Development
CNS Cancers
Gliomas, Glioblastomas
Pediatric Cancers
Small Molecule Agents
Kinase inhibitors
Translational Research
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