FLASHQuant: A Fast Algorithm for Proteoform Quantification in Top-Down Proteomics

Accurate quantification of individual proteoforms is a crucial step in identifying proteome-wide alterations in different biological conditions. Intact proteoforms have been analyzed predominantly by liquid chromatography–mass spectrometry (LC-MS)-based top-down proteomics (TDP) and quantified prima...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Jihyung Kim (7243529) (author)
مؤلفون آخرون:	Kyowon Jeong (6273380) (author), Philipp T. Kaulich (6408092) (author), Konrad Winkels (10661697) (author), Andreas Tholey (556130) (author), Oliver Kohlbacher (11422) (author)
منشور في:	2024
الموضوعات:	Biochemistry Medicine Sociology Plant Biology Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified perform highly accurate overlapping signals deriving https :// openms different biological conditions complex signal structures benchmark tests performed additional costly labeling quantifying coeluting proteoforms minutes per lc level lfq analysis flashquant /, accompanied proteomics accurate quantification intact proteoforms individual proteoforms reproducible quantification quantification accuracy proteoform quantification free quantification wide alterations source software short runtimes quantified primarily publicly available multiple lc ms runs ms run introduce flashquant independent open frequent coelution fast algorithm crucial step automatically resolving analyzed predominantly
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FLASHQuant: A Fast Algorithm for Proteoform Quantification in Top-Down Proteomics

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