Testing phenylbenzoxazole (PBZ) GroEL inhibitors for anti-Plasmodium activity.

A. Wildtype NF54 parasites were seeded at 0.5% parasitemia and incubated in serial dilutions of PBZ compounds, ranging from 50 μM to 50 nM. Parasitemia was measured after 72 or 96 hours to calculate the drugs’ half-maximal effective concentrations (EC50). Data are fit to...

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Autor principal:	Amanda Tissawak (21762930) (author)
Altres autors:	Yarden Rosin (21762933) (author), Shirly Katz Galay (21762936) (author), Alia Qasem (21762939) (author), Michal Shahar (15266558) (author), Nirit Trabelsi (21762942) (author), Ora Furman-Schueler (21762945) (author), Steven M. Johnson (17357) (author), Anat Florentin (21762948) (author)
Publicat:	2025
Matèries:	Biophysics Biochemistry Medicine Microbiology Cell Biology Genetics Pharmacology Evolutionary Biology Hematology Infectious Diseases Biological Sciences not elsewhere classified using genetic tools first replication cycle computational structural model additional targets outside previously unknown function synthesize essential biomolecules parasite death due div >< p cpn60 physically binds affect hs response apicoplast translation inhibitors apicoplast function work reveals taken together stable interface refolding safeguard plasmodium </ parasites serves organellar damage minimal control metabolic hub inactive forms immediately within heat shock evidence suggests eukaryotic cells endosymbiotic organelles directly involved conserved chaperonin close orthologues chaperonin inhibition cell nucleus caseinolytic protease balanced activities anti -<
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Testing phenylbenzoxazole (PBZ) GroEL inhibitors for anti-<i>Plasmodium</i> activity.

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