Selection frequency: Fraction of SigNet runs where a gene was selected as the active gene within its locus, averaged over 100 runs.

<p>Gene weight: Bayesian scores expressed as gene weights, as defined by <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012725#pcbi.1012725.e050" target="_blank">Eq (41)</a>, averaged over final values from the same 100 runs.</p&g...

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Bibliographic Details
Main Author:	Zeinab Mousavi (20521925) (author)
Other Authors:	Marios Arvanitis (528431) (author), ThuyVy Duong (18426903) (author), Jennifer A. Brody (7743146) (author), Alexis Battle (434619) (author), Nona Sotoodehnia (143373) (author), Ali Shojaie (213568) (author), Dan E. Arking (7588586) (author), Joel S. Bader (205554) (author)
Published:	2025
Subjects:	Genetics Molecular Biology Evolutionary Biology Developmental Biology Marine Biology Infectious Diseases Biological Sciences not elsewhere classified xlink "> motivation wide association studies snps ), associated new bayesian method span many genes selects 56 genes identified genetic variants minimum distance gene gwas loci overall 226 gwas loci likely causal gene gene distance method builds causal genes poor loci individual loci across loci causal variants causal remains nearby gene mendelian genes genes selected usually single usually affect significance networks pmp22 </ nucleotide polymorphisms linkage disequilibrium including disease human traits existing methods disease risk coding changes cardiac electrophysiology 20 %)
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Selection frequency: Fraction of SigNet runs where a gene was selected as the active gene within its locus, averaged over 100 runs.

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