Validation of the directed network flow entropy (DNFE) method based on simulation datasets.

<p>(A) The 11-node network model depicts positive regulation with arrows and negative regulation with solid lines. (B) The curve of the DNFE score derived from the gene regulatory network. (C) The landscape of the DNFE score for 11 nodes. (D) Assessment of the stability of DNFE compared to alt...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Xueqing Peng (10678527) (author)
مؤلفون آخرون:	Rui Qiao (458542) (author), Peiluan Li (6156950) (author), Luonan Chen (21547) (author)
منشور في:	2025
الموضوعات:	Biophysics Cell Biology Genetics Molecular Biology Developmental Biology Cancer Infectious Diseases Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Physical Sciences not elsewhere classified Information Systems not elsewhere classified xlink "> typically outperforms existing methods identified &# 8220 dynamic biological processes delay disastrous outcomes six real datasets one stable state detecting tipping points dynamic network biomarkers method &# 8217 including three single identifying critical states critical state tipping point cell datasets driving network directed network usually overlooked scale data sample data numerical simulations implemented based dimensional small cell rna cell data bulk data blood dataset
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Validation of the directed network flow entropy (DNFE) method based on simulation datasets.

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