How Do Molecular Crowders Influence Ligand Binding Kinetics with G‑Quadruplex DNA? The Role of Bound Water

Understanding the kinetics of ligand interaction with G-quadruplex DNA (GqDNA) in a crowded cell-like environment is of paramount importance in biology and pharmacology, as it elucidates the effect of molecular crowders on reaction rates governing these interactionsa process that largely remains un...

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Bibliographic Details
Main Author:	Parvez Alam (789093) (author)
Other Authors:	Ajay Kumar Chand (20540508) (author), Harsh Sahu (20540505) (author), Mostofa Ataur Rohman (6113954) (author), Ndege Simisi Clovis (7525541) (author), Deepika Sardana (7525538) (author), Sanjay Puri (3860725) (author), Sobhan Sen (1288998) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Molecular Biology Pharmacology Biotechnology Cancer Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified strong electrostatic forces stacking electrostatic forces reaction rates governing largely remains unexplored dissociation rate (< current investigation underscores association rate (< bound water understanding molecular plane relative eg ), peg200 ligand binding mode ligand binding affinity binding affinity lived water cv ), molecular dynamics stacked ligand ligand ’ ligand interaction molecular crowders without 10 quadruplex dna primarily driven paramount importance like environment k </ interactions  induced decrease ethylene glycol disruption weakens crowded milieu crowded cell cresyl violet concomitant increase causing rotation bond interactions bond bridges
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How Do Molecular Crowders Influence Ligand Binding Kinetics with G‑Quadruplex DNA? The Role of Bound Water

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