In this figure we show the output of the half-loop biclustering algorithm applied to the BDRN cohort in arm-1 (limited to those SNPs with maf ≥0.25).

In this figure we show the output of the half-loop biclustering algorithm applied to the BDRN cohort in arm-1 (limited to those SNPs with maf ≥0.25).

<p>As described in the main text, the algorithm proceeds iteratively, eliminating rows and columns from the case-subject-array <i>D</i> until all have been removed. At each iteration <i>i</i>, the remaining submatrix <i>D</i>(<i>i</i>) comprises...

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Bibliographic Details
Main Author:	Caroline C. McGrouther (5216153) (author)
Other Authors:	Aaditya V. Rangan (14659986) (author), Arianna Di Florio (20636356) (author), Jeremy A. Elman (9602147) (author), Nicholas J. Schork (176346) (author), John Kelsoe (3437189) (author)
Published:	2025
Subjects:	Genetics Neuroscience Pharmacology Biotechnology Evolutionary Biology Marine Biology Mental Health Infectious Diseases Plant Biology Biological Sciences not elsewhere classified termed &# 8216 psychiatric genomics consortium leverage recent advances e ., biclusters corrected biclustering algorithm subgroup may represent subgroup &# 8217 pgc containing 5781 various bd studies bd subtype information improve risk prediction specific pattern highlighted homogeneous genetic subgroup relatively small subset genetically homogeneous subtype discovered without using bicluster &# 8217 specific genetic pattern correlated genetic risk 2524 bd cases genetic heterogeneity delineating disorder </ p specific pattern genetic subgroup bd cases genetic level genetic data pgc ). 9752 cases bipolar disorder xlink "> successfully identified subphenotypic data subjects define set aside remaining data related signal prs ), primary focus particularly notable one way informed polygenic gwas analyses fully understood first apply expression across eliminate noise driven subgroups challenging task broad phenotype
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