Photoaffinity Ligand of Cystic Fibrosis Corrector VX-445 Identifies SCCPDH as an Off-Target

Cystic fibrosis (CF) pharmacological correctors improve the cystic fibrosis transmembrane conductance regulator (CFTR) protein trafficking and function. Several side effects of these correctors and adverse drug interactions have been reported, emphasizing the need to understand off-targets. We synth...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Minsoo Kim (171626) (author)
مؤلفون آخرون:	Kwangho Kim (1343724) (author), Jesun Lee (21577553) (author), Lea A. Barny (14555843) (author), Toya D. Scaggs (6824642) (author), Ian M. Romaine (335211) (author), KyuOk Jeon (19333198) (author), Simona G. Codreanu (2195107) (author), Stacy D. Sherrod (1325025) (author), John A. McLean (696579) (author), Anjaparavanda P. Naren (21577556) (author), Gary A. Sulikowski (214879) (author), Lars Plate (1265706) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Cell Biology Genetics Molecular Biology Neuroscience Pharmacology Immunology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified several side effects psychological symptoms observed potential inhibitory activity data show dysregulation amino acid metabolism also characterized changes adverse drug interactions uncharacterized putative oxidoreductase target may explain target cystic fibrosis cells overexpressing sccpdh pharmacological correctors improve identified saccharopine dehydrogenase functionalized photoaffinity ligand 445 identifies sccpdh photoaffinity ligand like oxidoreductase sccpdh ), synthesized vu439 protein trafficking metabolomic profiles mass spectrometry linked proteins identify cross chemoproteomics analysis
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Photoaffinity Ligand of Cystic Fibrosis Corrector VX-445 Identifies SCCPDH as an Off-Target

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