Age-associated metabolic profiles of dInrE19/dInr74 and dInr353/dInrwt.

(A) Heatmap of age-associated metabolites among wildtype (dInrwt/wt), dInrE19/dInr74, or dInr</i...

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Bibliographic Details
Main Author:	Marc Tatar (68517) (author)
Other Authors:	Wenjing Zheng (497844) (author), Shweta Yadav (687511) (author), Rochele Yamamoto (9772333) (author), Noelle Curtis-Joseph (19241632) (author), Shengxi Li (5869568) (author), Lin Wang (11986) (author), Andrey A. Parkhitko (10151469) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Physiology Evolutionary Biology Developmental Biology Computational Biology Chemical Sciences not elsewhere classified reroute methionine toward reprograms methionine metabolism methionine cycle reprogramming like receptor (< kinase insert domain dominant mutation (< adenosylhomocysteine hydrolase blocks robustly extends longevity mutant flies upregulate longevity benefit conferred div >< p unlike aged wildtype slow aging without transsulfuration pathway continuously 353 </ sup ii mutants overlap type ii mutant slow aging >< sup transsulfuration pathway type ii extend longevity drosophila </ dinr </ conserved pathway kid mutant young age weakly fecund reproductive functions recently developed multiple mechanisms metabolomic analysis metabolomic analyses metabolome analyses metabolically flexible many pathways innate immune include differences highly fecund extend lifespan applied transcriptome >) mutants
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Age-associated metabolic profiles of <i>dInr</i><sup><i>E19</i></sup>/<i>dInr</i><sup><i>74</i></sup> and <i>dInr</i><sup>353</sup>/<i>dInr</i><sup>wt</sup>.