Ufisonitriles A and B, Antimalarial Isonitriles with Mitochondrial Function Inhibitory Activity Produced by Amycolatopsis sp. OK19-0009

Two novel antimalarials, named ufisonitriles A (1) and B (2), were isolated by bioassay-guided fractionation on mitochondrial function inhibitory activity using multidrug-sensitive budding yeast from the cultured broth of the Okinawan rare actinomycete ...

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Main Author:	Emi Arakawa (22336677) (author)
Other Authors:	Yoshihiro Watanabe (2072284) (author), Hayama Tsutsumi (5242409) (author), Akari Ikeda (1944484) (author), Tomoyasu Hirose (1577314) (author), Noriko Sato (201880) (author), Takumi Chinen (1457128) (author), Akira Také (6447860) (author), Hiroki Kanto (14787341) (author), Yuki Inahashi (1652035) (author), Takahiro Ishii (738125) (author), Toshiaki Teruya (2340349) (author), Toshiaki Sunazuka (1577323) (author), Hideaki Hanaki (1909276) (author), Takeo Usui (486328) (author), Rei Hokari (2862743) (author), Aki Ishiyama (1652050) (author), Yukihiro Asami (287547) (author), Masato Iwatsuki (1652047) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Cell Biology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified sensitive budding yeast okinawan rare actinomycete modified mosher ’ genome sequence analysis exhibited moderate activity 2d nmr analyses plasmodium falciparum </ 2 </ b 50 </ sub b (< b 1 </ b (< b vivo </ vitro </ amycolatopsis </ values ranging strains revealed observed toxicity novel skeleton malaria parasites isocyano group intraperitoneal administration guided fractionation cultured broth approximately 45 antimalarial isonitriles antimalarial evaluation also provide 4 days 30 mg 12 μm 0009 strain
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Ufisonitriles A and B, Antimalarial Isonitriles with Mitochondrial Function Inhibitory Activity Produced by <i>Amycolatopsis</i> sp. OK19-0009

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