Schematic showing the metabolite-cell signaling-gene regulatory circuit connecting mTORC2/RICTOR signaling to ganglioside metabolism, regulating uncontrolled breast cancer cell proliferation.

<p>Stages 1–8 sequentially represent the mTORC2/RICTOR signaling-mediated epigenetic regulations modulating UGCG transcription, which leads to ganglioside-mediated EGFR activation and tumor progression. The solid black lines represent increased activation and signaling in the circuit, whereas...

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Main Author:	Mohammad Nafees Ansari (22232505) (author)
Other Authors:	Somesh K. Jha (20722073) (author), Ali Khan (568900) (author), Kajal Rajput (11403230) (author), Nishant Pandey (5578880) (author), Dolly Jain (11403227) (author), Rajeshwari Tripathi (22232508) (author), Nihal Medatwal (4251403) (author), Pankaj Sharma (58141) (author), Sudeshna Datta (3643081) (author), Animesh Kar (4583296) (author), Trishna Pani (22232511) (author), Sk Asif Ali (22232514) (author), Kaushavi Cholke (19669386) (author), Kajal Rana (11403212) (author), Valiya P. Snijesh (22232517) (author), Geetashree Mukherjee (264708) (author), Suryanarayana V. S. Deo (22232520) (author), Soumen Basak (1681390) (author), Ashutosh Mishra (231926) (author), Jyothi S. Prabhu (3173547) (author), Arnab Mukhopadhyay (5645819) (author), Avinash Bajaj (1910212) (author), Ujjaini Dasgupta (7483922) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Genetics Molecular Biology Developmental Biology Cancer Hematology Plant Biology Computational Biology Chemical Sciences not elsewhere classified dna methyltransferase 1 human cell culture cancer cell proliferation key regulatory circuit ganglioside metabolic pathways div >< p promoting ganglioside biosynthesis known akt substrates egfr signaling pathway cell signaling ganglioside biosynthesis regulatory subunit less known specific mcf mouse models metabric datasets mammalian cells kdm5a ), histone demethylase established roles epigenetic mechanisms crucial components 474 cells
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Schematic showing the metabolite-cell signaling-gene regulatory circuit connecting mTORC2/RICTOR signaling to ganglioside metabolism, regulating uncontrolled breast cancer cell proliferation.

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