CYP gene expression of indoxyl sulfate (IS) in primary human hepatocytes.

<p>GAPDH (glyceraldehyde-3-phosphate dehydrogenase) was used as an internal standard, and the expression of each gene was expressed as the ratio of the respective solvent (negative control). Water was used as the solvent for the IS and phenobarbital, and dimethyl sulfoxide (DMSO, final concent...

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Váldodahkki:	Masao Togao (21696599) (author)
Eará dahkkit:	Naoyuki Asakawa (3065967) (author), Gaku Wagai (21696602) (author), Yuki Ohta-Takada (21696605) (author), Jun Otsuka (4442653) (author), Minoru Ando (21696608) (author), Akinobu Kurita (11645308) (author), Koji Kawakami (193636) (author)
Almmustuhtton:	2025
Fáttát:	Biochemistry Microbiology Genetics Molecular Biology Science Policy Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified various gut microbiota pregnane x receptor identify gut microbiota level gut microbiota indole propionic acid study advocates accounting derived metabolites governing cyp3a activity decreased affect cyp3a activity derived metabolites lithocholic acid study demonstrates study aimed hepatic cyp3a xlink "> uremic toxin transcriptional regulator three donors results revealed primary hepatocytes one donor indoxyl sulfate dependent impact cause variations blood level
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CYP gene expression of indoxyl sulfate (IS) in primary human hepatocytes.

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