Enzymatic Insights into the Unusual Formation of Benzolactone and Benzopyran in the Biosynthesis of Spiromarmycin

Spiromarmycin-type natural products are rare fungal tricyclic aromatic polyketides with remarkable biological activities. However, the enzymatic processes for assembling the lactone and pyran ring of spiromarmycin and its analogues are unclear. Here, we identify a rare benzolactone formation process...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Yingying Chen (500738) (author)
مؤلفون آخرون:	Linqian Jing (20648687) (author), Ming Peng (553908) (author), Cunlei Cai (14298949) (author), Junjie Shi (391734) (author), Wen Ge (4908967) (author), Yang Liu (4829) (author), Zhuo Shang (1457281) (author), Junying Ma (466656) (author), Dalei Wu (8897453) (author), Jianhua Ju (773073) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Genetics Pharmacology Biotechnology Cancer Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified unique spontaneous anti typical thioesterase domain type natural products toxic final product thus avoiding self sup >+</ sup subsequent molecular docking remarkable biological activities future drug discovery drug precursor synthesis c6 hydroxy preset based catalytic mechanism unusual formation substrate accommodation study advances structural analysis role instead pyran ring potential application high stereoselectivity extracellular space epoxide intermediate epoxide hydrolase enzymatic processes enzymatic insights critical role chain dehydrogenase catalyzed transesterification biocatalytic toolbox baldwin cyclization apo form
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Enzymatic Insights into the Unusual Formation of Benzolactone and Benzopyran in the Biosynthesis of Spiromarmycin

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