Single-cell transcriptomic profiling of control and <i>Wt1</i><sup>Cre</sup>; <i>Sox9</i><sup>fl/fl</sup>; <i>R26</i><sup>mG</sup> epicardial cells.

Single-cell transcriptomic profiling of control and <i>Wt1</i><sup>Cre</sup>; <i>Sox9</i><sup>fl/fl</sup>; <i>R26</i><sup>mG</sup> epicardial cells.

<p><b>(A)</b> UMAP depicting a subsetting and reclustering of the epicardial cell cluster. <b>(B)</b> Feature plots of epicardial marker <i>Wt1</i> and reporter transcript <i>Egfp</i> indicated expression in all subpopulations of epicardial cells...

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Main Author: Andrew B. Harvey (21587431) (author)
Other Authors: Allison M. Trouten (21587434) (author), Renélyn A. Wolters (21587437) (author), Jenna R. Drummond (21587440) (author), Raymond N. Deepe (21587443) (author), Hannah G. Tarolli (21587446) (author), Inara Devji (21587449) (author), Silvia G. Vaena (18199268) (author), Martin J. Romeo (18199271) (author), Robin Muise-Helmericks (6731099) (author), Paula S. Ramos (15244255) (author), Russell A. Norris (9310451) (author), Ge Tao (3953639) (author), Andy Wessels (382418) (author)
Published: 2025
Subjects:
Medicine
Cell Biology
Genetics
Molecular Biology
Developmental Biology
Cancer
Hematology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
ventricular myocardium associated
investigate broader roles
gene encoding sry
div >< p
atrioventricular valve mesenchyme
mesenchymal transformation consistent
coronary vasculature development
cell types essential
coronary vascular development
derived cell invasion
vascular development
cell invasion
mesenchymal cells
cell rna
heart development
epicardial invasion
use single
specific deletion
progenitor cells
mural cells
mesothelial lining
invasive population
insights provide
histological observations
giving rise
cardiac fibroblasts
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