High-Throughput Site-Specific N‑Glycosylation Profiling of Human Fibrinogen in Atrial Fibrillation

High-Throughput Site-Specific N‑Glycosylation Profiling of Human Fibrinogen in Atrial Fibrillation

Fibrinogen is a major plasma glycoprotein involved in blood coagulation and inflammatory responses. Alterations in its glycosylation have been implicated in various pathological conditions; yet, its site-specific N-glycosylation profile remains largely unexplored in a clinical context. Here, we pres...

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Main Author: Dinko Šoić (20893983) (author)
Other Authors: Domagoj Kifer (6001808) (author), Janko Szavits-Nossan (20893986) (author), Aleksandar Blivajs (20893989) (author), Lovorka Đerek (14997984) (author), Diana Rudan (20893992) (author), Olga Gornik (234304) (author), Ivan Gudelj (3990350) (author), Toma Keser (278294) (author)
Published: 2025
Subjects:
Biochemistry
Cell Biology
Genetics
Physiology
Immunology
Cancer
Hematology
Infectious Diseases
Chemical Sciences not elsewhere classified
promote clot formation
intraindividual temporal stability
associated glycan profile
181 atrial fibrillation
12 %, respectively
various pathological conditions
cardiovascular risk factors
atrial fibrillation fibrinogen
specific glycosylation analysis
cardiovascular conditions
specific analysis
specific n
longitudinal analysis
human fibrinogen
fibrinogen n
throughput lc
prothrombotic state
potential biomarker
ms workflow
interplate repeatability
inflammatory responses
increased levels
including triglycerides
healthy individuals
glycosylation using
glucose levels
first assessment
clinical context
clinical applications
blood coagulation
asialylated n4h5
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