HSP90 inhibition by RGRN-305 decreased the gene expression of proinflammatory cytokines induced by SARS-CoV-2 S protein.

HSP90 inhibition by RGRN-305 decreased the gene expression of proinflammatory cytokines induced by SARS-CoV-2 S protein.

<p>RGRN-305 (HSP90 inhibitor) inhibited the mRNA expression of <i>TNF</i>, <i>IL1β</i> and <i>IL6</i> induced by SARS-CoV-2 S protein in human macrophage-like U937 and human lung epithelial A549 cells. <b>(A)</b> U937 macrophage-like cells were p...

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Bibliographic Details
Main Author:	Hakim Ben Abdallah (14578241) (author)
Other Authors:	Giorgia Marino (19193697) (author), Manja Idorn (770510) (author), Line S. Reinert (5048120) (author), Anne Bregnhøj (14578244) (author), Søren Riis Paludan (9261725) (author), Claus Johansen (367892) (author)
Published:	2024
Subjects:	Biochemistry Microbiology Cell Biology Molecular Biology Pharmacology Biotechnology Immunology Cancer Infectious Diseases Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified div >< p coronavirus disease 2019 potential treatment strategy inflammatory response induced htmprss2 cells infected exhibits strong anti 2 spike protein 305 significantly dampened 305 attenuates sars like cells inflammatory properties induced inflammation 305 treatment 19 treatment 305 may 305 exacerbates vitro </ viral shedding viral replication viral infections tnf </ time pcr survived compared significantly reduced quantitative real proinflammatory cytokines murine model mrna expression molecular chaperone mice infected lacks effectiveness il6 </ il1b </ human macrophage day 12 data suggest data shows cytopathic effect beneficial impact animal weight a549 ). 2 infection 2 ). 19 ).
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