An analysis of H3K27Ac standardized counts visualizes the similarities in signal shape contrasted by the variations at peaks.

<p>H3K27Ac counts of all the GSC datasets around TSS are visualized at bin levels. A) Visualizing H3K27Ac signals for all genes, regardless of their RNA-seq values. All these GSCs have similar H3K27Ac epigenetic landscapes with two distinct peaks B) H3K27Ac signals for “high” expressing genes...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Yusuke Suita (14381481) (author)
مؤلفون آخرون:	Hardy Bright Jr (22008830) (author), Yuan Pu (3509042) (author), Merih Deniz Toruner (22008833) (author), Jordan Idehen (22008836) (author), Nikos Tapinos (152991) (author), Ritambhara Singh (689753) (author)
منشور في:	2025
الموضوعات:	Cell Biology Genetics Molecular Biology Developmental Biology Cancer Infectious Diseases Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Information Systems not elsewhere classified providing valuable insights mechanisms dynamically regulate improving glioblastoma outcomes glioblastoma stem cells evade targeted therapies investigate different ml enhancer activity characterized predict gene expression gene expression provides one patient generalizes common distributional pattern combining epigenetic features h3k27ac peaks across glioblastoma </ p driving transcript expression using machine learning gscs ), contributing common epigenetic pattern gscs across patients ml ), transcript expression machine learning enhancer activation single patient patient prediction deep learning epigenetic drivers eradicating gscs enabling gscs various sources ultimately build tumor heterogeneity therapeutic resistance targeting strategies rnapii chip resistant mesenchymal remarkably similar phenotypic plasticity phenotypic heterogeneity model trained like phenotypes key oncogenic including therapy including atac high performance h3k27ac chip h3k27ac alone findings suggest environmental cues employ cross
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An analysis of H3K27Ac standardized counts visualizes the similarities in signal shape contrasted by the variations at peaks.

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