New Mesoionic Pyrido[1,2‑<i>a</i>] Pyrimidines Containing Oxime Esters against Megoura japonica with Better Safety to Pollinating Insects

The selectivity of pesticides for harmful insects versus beneficial organisms has long been a critical issue in agriculture. Pyrido[1,2-<i>a</i>] pyrimidine mesoionics have been widely demonstrated to effectively control a diverse range of insect pests. However, many of their analogues h...

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Bibliographic Details
Main Author:	Hui Zhang (7197) (author)
Other Authors:	Shang Wu (7497509) (author), Wenchao Wei (9132760) (author), Yuqin Luo (7371020) (author), Zhongjie Shen (14316779) (author), Ruilan Wang (12841616) (author), Baoan Song (162306) (author), Runjiang Song (3091920) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Genetics Neuroscience Ecology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified proteomic analyses suggest oxime ester functionalization median lethal dose median lethal concentration exhibited high toxicity acute contact experiments >] pyrimidines designed >] pyrimidine mesoionics positive control triflumezopyrim penetration mechanism indicate molecular dynamics simulations wz18 </ b 50 </ sub new mesoionic pyrido similar mechanism new analogue molecular docking mesoionic insecticides effectively control widely demonstrated valuable foundation systemic property study provides slightly lower primarily due pollinating insects nontarget organisms nervous system megoura japonica may interfere likely shares insecticidal activity diverse range critical issue better safety 73 μg 25 μg 2 ‑< 2 -< 06 μg 05 μg ./ bee
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New Mesoionic Pyrido[1,2‑<i>a</i>] Pyrimidines Containing Oxime Esters against Megoura japonica with Better Safety to Pollinating Insects

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