Glutamine deficiency enhances nuclear localization of TCA cycle enzymes and epigenetic modifications, impairing myogenesis
<p dir="ltr">This study revealed that extracellular Gln regulates MPC proliferation through metabolic-epigenetic axis. Gln deficiency impairs myogenesis, enhances the nuclear localization of TCA cycle enzyme, increases histone succinylation, and reduces chromatin accessibility at the...
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2025
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