Correlations between the mtDNA score and immunotherapy response.

<p>A. Expression of PD-L1 in the low-mtDNA score group and high-mtDNA score group. B. Analysis of differences in the response to CTLA-4 negative and PD-1 negative therapy between the low mtDNA score group and high mtDNA score group. C. Analysis of the difference in anti-PD-1 immunotherapy effi...

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Bibliographic Details
Main Author:	Fan Rong (11587366) (author)
Other Authors:	Bin Cheng (64483) (author), Ling Guo (9700) (author), Shaobo Zeng (12967968) (author), Xunliang Xu (19510705) (author), Zhongji Meng (413705) (author)
Published:	2025
Subjects:	Biochemistry Genetics Molecular Biology Biotechnology Immunology Cancer Virology Biological Sciences not elsewhere classified xlink "> data treatment decision making thereby providing guidance machine learning model high mutation burden high clinical stage different molecular subtypes three gene subtypes tumor mutation burden principal component analysis mitochondrial dna maintenance important genetic material cancer genome atlas unsupervised clustering based immune infiltration profiles 740 core genes mtdna score model high mtdna score gene expression omnibus 487 hcc samples 22 mtdna mrgs evaluate hcc prognosis mtdna score mtdna mrgs related gene hcc samples tumor microenvironment mitochondrial dysfunction genetic variation correlation analysis 22 genes cancer progression cancer prognosis mtdna mrg hcc prognosis vs .</ variants contribute subsequently constructed related genes prognosis prediction normal controls immune rejection immune microenvironment immune inflammation hepatocellular carcinoma geo ). eukaryotic cells desert phenotypes clinicopathological features biological processes
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Correlations between the mtDNA score and immunotherapy response.

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