OpioidBias: A Machine Learning Tool for Predicting the Biased Agonism of Opioid Ligands

OpioidBias: A Machine Learning Tool for Predicting the Biased Agonism of Opioid Ligands

Biased signaling at G-protein-coupled receptors (GPCRs) enables pathway-selective modulation but remains challenging to characterize experimentally. We present OpioidBias, a machine learning tool for predicting G-protein versus β-arrestin bias in opioid ligands. A curated data set of opioid ligands...

Shranjeno v:

Bibliografske podrobnosti
Glavni avtor:	Rajkumar R (22674565) (author)
Drugi avtorji:	Anju Sharma (2900093) (author), Anuradha Badade (22674568) (author), Tanmaykumar Varma (17013628) (author), Prabha Garg (1625956) (author)
Izdano:	2025
Teme:	Biochemistry Molecular Biology Cancer Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified recursive feature elimination machine learning tool identify molecular determinants http :// github curated data set protein versus β six classifiers selective modulation remains challenging opioid ligands freely available encompassing physicochemical enables pathway coupled receptors characterize experimentally biased agonism best performance based features 3800 descriptors
Oznake:	Označite Brez oznak, prvi označite!

Podobne knjige/članki

OpioidBias: A Machine Learning Tool for Predicting the Biased Agonism of Opioid Ligands
od: Rajkumar R (22674565)
Izdano: (2025)

OpioidBias: A Machine Learning Tool for Predicting the Biased Agonism of Opioid Ligands
od: Rajkumar R (22674565)
Izdano: (2025)

OpioidBias: A Machine Learning Tool for Predicting the Biased Agonism of Opioid Ligands
od: Rajkumar R (22674565)
Izdano: (2025)

OpioidBias: A Machine Learning Tool for Predicting the Biased Agonism of Opioid Ligands
od: Rajkumar R (22674565)
Izdano: (2025)

OpioidBias: A Machine Learning Tool for Predicting the Biased Agonism of Opioid Ligands
od: Rajkumar R (22674565)
Izdano: (2025)

The Male Primary Sex Ratio Bias in Goose Eggs Early in the Laying Season: A Pilot Study
od: Valeriy G. Narushin (17784130)
Izdano: (2025)

Supplementary file 1_Trend analysis and future projections of global burden of opioid use disorder (OUD) from 1990 to 2030.docx
od: Wenshuo Jiang (22679207)
Izdano: (2025)

Supplementary file 2_Trend analysis and future projections of global burden of opioid use disorder (OUD) from 1990 to 2030.docx
od: Wenshuo Jiang (22679207)
Izdano: (2025)

Quality and Bias Assessment.
od: R. Constance Wiener (13104494)
Izdano: (2025)

A QM-AI Approach for the Acceleration of Accurate Assessments of Halogen‑π Interactions by Training Neural Networks
od: Marc U. Engelhardt (16642483)
Izdano: (2025)

Relative bias of the App-results.
od: Jette Hinrichsen (22683252)
Izdano: (2025)

The Cykloid-Adelic Recursive Expansive Field Equation (CARE)
od: Del Bel, Julian (21403013)
Izdano: (2025)

Adelic Aligned p-adic Spacetime and Recursive Expansive Dynamics
od: Del Bel, Julian (21403013)
Izdano: (2025)

لتنظيم تشريعي أكثر عدالة لقانون الأحوال الشخصية الأردني رقم (15) لعام 2019م: الحضانة أنموذجاً
od: Hunaiti, Sana J
Izdano: (2021)

Mathematical Lifting of Eigenvergence in Recursive Expansive Dynamics
od: Julian Del Bel (21360938)
Izdano: (2025)

Dataset for ALS Progression Prediction Study
od: SWASTHIKA BHASKAR (22677956)
Izdano: (2025)

<b>data for Linking AMOC Weakening </b><b>to </b><b>the Double-ITCZ</b><b> Bias in Coupled Climate Models</b>
od: haonan lu (22681124)
Izdano: (2025)

Textural changes are more sensitive than volumetry of amygdala in cocaine use disorder patients: potential for low field translation
od: Shounak Nandi (22675916)
Izdano: (2025)

Supplementary Material for: Even number bias in pulse oximetry measurements in hospitals in Denmark and the United Kingdom: an observational study
od: figshare admin karger (2628495)
Izdano: (2025)

Data Sheet 1_Enhancing preoperative HER2 status classification of invasive breast cancers using machine learning models based on clinicopathological and MRI features: a multicenter study.docx
od: Suhong Zhao (10057478)
Izdano: (2025)

Data Sheet 1_Snoring sound classification in patients with cerebrovascular stenosis based on an improved ConvNeXt model.pdf
od: Caijian Hua (10169614)
Izdano: (2025)

Supplementary file 1_Bacteriocin prediction through cross-validation-based and hypergraph-based feature evaluation approaches.docx
od: Suraiya Akhter (22679093)
Izdano: (2025)

<b>Minimal repeats identified by machine learning as novel cross-species markers of translation initiation sites</b>
od: Ali Mohammad Ali Maddi (11301486)
Izdano: (2025)

Synthetic Aperture Radar as a Tool for Tornado Classification in Forested Areas
od: Sophia G. Slabon (22677053)
Izdano: (2025)

Machine Learning-Driven Cross-Species Toxicity Prediction for Advancing Ecologically Relevant PFAS Water Quality Criteria
od: Weigang Liang (734333)
Izdano: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
od: Neval Yilmaz (1544557)
Izdano: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
od: Neval Yilmaz (1544557)
Izdano: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
od: Neval Yilmaz (1544557)
Izdano: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
od: Neval Yilmaz (1544557)
Izdano: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
od: Neval Yilmaz (1544557)
Izdano: (2025)

<b>Structural Determinants of Non-Covalent PPARγ Inverse Agonism and Their Therapeutic Implications</b>
od: Kuang-Ting Kuo (21682520)
Izdano: (2025)

Technoeconomic Tools for Low Carbon SAF Production and Equitablity Framework for Low Carbon Fuels
od: Muhammad Haider Khan (14035974)
Izdano: (2025)

Solvent-Site Prediction for Fragment Docking and Its Implication on Fragment-Based Drug Discovery
od: Laura Almena Rodriguez (21008567)
Izdano: (2025)

Solvent-Site Prediction for Fragment Docking and Its Implication on Fragment-Based Drug Discovery
od: Laura Almena Rodriguez (21008567)
Izdano: (2025)

Solvent-Site Prediction for Fragment Docking and Its Implication on Fragment-Based Drug Discovery
od: Laura Almena Rodriguez (21008567)
Izdano: (2025)

Differences in personality traits between sorted and desired houses for people who were sorted against their preference – Helmert contrasts.
od: Lidia Baran (9322815)
Izdano: (2025)

Differences between houses (desired) – Helmert contrasts.
od: Lidia Baran (9322815)
Izdano: (2025)

Differences between houses (sorted) – Helmert contrasts.
od: Lidia Baran (9322815)
Izdano: (2025)

Descriptive statistics for all variables.
od: Lidia Baran (9322815)
Izdano: (2025)

Psychological traits characteristic for members of each of the Hogwarts Houses.
od: Lidia Baran (9322815)
Izdano: (2025)

Cannot write session to /tmp/vufind_sessions/sess_i5o2ovflm7kfdnq8juq80f6fvk